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Prof. Dr. Julien Furrer

Born 1975 in Strasbourg, France.

1978 - 1993

Elementary school, collège, lycée, Strasbourg.

06/1993

Baccalaureate D, Mathematics and natural sciences.

09/1993 - 06/1997

Study of  Chemistry and physical chemistry. University Louis Pasteur, Strasbourg.

09/1997 - 06/1998

DEA in physical chemistry, University Louis Pasteur, Strasbourg. DEA thesis "the High Resolution Magic Angle Spinning (HRMAS) applied to resin-bound molecules". Supervision: Prof. Dr. P. Granger, Dr. K. Elbayed.

09/1998 - 06/2001

PhD in physical chemistry,  University Louis Pasteur, Strasbourg. "Methodological and Experimental aspects of the High Resolution Magic Angle Spinning (HRMAS) applied to
resinbound molecules". Supervision: Dr. K. Elbayed, Dr. M. Piotto.

10/2001 - 01/2004

Postdoctoral Fellow, Alexander von Humboldt Fellowship. Instiute for organic chemistry and biochemistry, TU Munich, Germany. Supervision: Prof. Dr. H. Kessler, Prof. Dr. B. Luy.

02/2004 - 01/2007

Assistant "Akademischer Rat", head of the NMR facilities. Organic Chemistry Institute, University of Heidelberg, Germany.

02/2007 - 12/2010

Engineer, head of the NMR facilities. University of Neuchâtel, Switzerland.

Since 01/2011

Dozent, head of the NMR facilities. Department of chemistry and biochemistry, University of Bern, Switzerland. 2012 Habilitation.

Publications:

www.dcb.unibe.ch/ueber_uns/personen/pd_dr_furrer_julien/index_ger.html#pane110641

ORCID

researcherID

Research Interests

High Resolution Magic Angle Spinning (HRMAS)

 

- Origin of the NMR linewidth of resin bound compounds
- Monitoring of multi-step synthesis on solid supports using HRMAS
- Structure of bioactive peptides bound to solid supports
- Proton dipolar recoupling in resin bound peptides
- Suspension NMR of ionic liquides immobilized on silica

Solution strucutral studies

 

  • - Backbone assignment of the p63 protein
    - N-terminal domain of Hsp90 upon ligand binding
    - Structure of an alpha3beta1 integrin-binding peptide
    - Antimalarial drugs
    - Self-assembled metallo-prismatic cations
    - Bioconjugates of Aminolevulinic acid
    - chiral fullerodendrimers
    - host-guest studies between Ruthenium cages and various arenes
    - Structure of bicyclic homodetic peptides
    - Stimuli-Responsive Arene Ruthenium Metalla-Prism

Cellular targets and mechanistic profiles of ruthenium-based drugs

 

  • - Dinuclear arene ruthenium trithiolato complexes
    - Ru-hexacationic prism
    - Hexanuclear Thiolato-Bridged Arene Ruthenium Metalla-Prisms
    - Metal Complexes as Catalysts in Living Cells and Organisms

Residual dipolar couplings

 

  • - Properties of stretched polystyrene gels

Experimental methods

 

  • - Relaxation-optimized homonuclear Hartmann-Hahn (MOCCA sequences)
    - Accordion-BIRD HMBC experiments
    - J-spectroscopy in the presence of RDCs: 3D JE-HSQC experiments
    - The CLIP/CLAP HSQC experiment
    - The G-BIRD-HMBC experiment
    - Accordion-optimized DEPT experiments
    - The IMPACT-HMBC experiment
    - Recent advances in HMBC studies
    - Optimized 1D-GROESY experiments
    - NMR Experiments for the analysis of mixtures
    - Comprehensive Discussion of HMBC Pulse Sequences

Others

 

    - Destruction of magnetization during TOCSY: radial B1 inhomogeneities